RESUMO
Background Congenital hyperinsulinism (CH) is the most frequent cause of persistent hypoglycemia in the newborn. Octreotide, a long-acting somatostatin receptor analog (SSRA), is a second line treatment for diazoxide unresponsive CH patients. Although it has been found to be a safe and effective treatment, long-term benefits and side effects, have not been thoroughly evaluated. Case presentation Some authors have indicated that exocrine pancreatic insufficiency (EPI) is a common but under-recognized adverse reaction in adults treated with octreotide. However, no pediatric patient with SSRA-induced EPI has been reported to date. Here we report a case of an infant with diazoxide unresponsive, diffuse CH, caused by a heterozygous pathogenic paternally inherited mutation in the ABCC8 gene (NM_000352.4:c.357del), that developed exocrine pancreatic insufficiency and secondary vitamin K deficiency associated to chronic octreotide therapy. Conclusions We point out the atypical clinical onset with a cutaneous hemorrhagic syndrome, emphasizing the clinical relevance of this potential side effect.
Assuntos
Hiperinsulinismo Congênito/tratamento farmacológico , Insuficiência Pancreática Exócrina/induzido quimicamente , Octreotida/efeitos adversos , Hiperinsulinismo Congênito/sangue , Hiperinsulinismo Congênito/genética , Diazóxido/uso terapêutico , Insuficiência Pancreática Exócrina/terapia , Hemorragia/diagnóstico , Hemorragia/etiologia , Hemorragia/terapia , Humanos , Lactente , Masculino , Octreotida/uso terapêutico , Receptores de Sulfonilureias/genéticaRESUMO
Research on the prevalence and correlates of dating violence in Mexican teens is challenged by the lack of culturally and linguistically appropriate assessment tools. This study modified, translated, and back-translated the Conflict in Adolescent Dating Relationships Inventory (CADRI; Wolfe et al., 2001) and the Attitudes Towards Dating Violence Scales (Price, Byers, & the Dating Violence Research Team, 1999) for Mexican adolescents. Analyses on 307 adolescents (15-18 years old) from Monterrey and Mexicali, Mexico, revealed that most of the translated CADRI subscales and Attitudes Towards Dating Violence Scales had acceptable internal consistency and test-retest reliability coefficients. The study offers some evidence that the measures may be useful in assessing dating violence in Mexican teens.
